The Newberry County Sheriff's Office has arrested the estranged husband of 72-year-old Andrenna Butler in her murder.
Sheriff Lee Foster says 76-year-old Charles Butler is charged with fatally shooting his wife in the head.
Mrs. Butler was found unresponsive in her Newberry home by a friend on Saturday after she could not be reached repeatedly by phone.
Foster says investigating officers used a variety of forensic techniques to tie the husband to the crime scene and the murder.
The couple had been married for over 50 years prior to their separation and the husband moving to Chambersburg, Pennsylvania.
Charles Butler is being held on arrest warrants and is awaiting extradition hearings.
Foster says the murder is the result of a domestic issue stemming from the separation.